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Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study.
Holmes VA (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Holmes%20VA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVCitation), Wallace JM (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Wallace%20JM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVCitation), Gilmore WS (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Gilmore%20WS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVCitation), McFaul P (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22McFaul%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVCitation), Alexander HD (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=Search&Term=%22Alexander%20HD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVCitation).
Northern Ireland Centre for Diet and Health (NICHE), University of Ulster, BT52 1SA, Northern Ireland, Coleraine, UK. v.holmes@qub.ac.uk
Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve foetal survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case-control study, the physiological effect of pregnancy on plasma IL-10 was investigated. The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12, 20 and 35 weeks of gestation, 38 non-pregnant control subjects sampled in parallel and in a subgroup of women sampled at 3 days post-partum (n, pregnant 21, non-pregnant 21). Plasma IL-10 was significantly higher in pregnant women at 12, 20 and 35 weeks of gestation (p<0.05, p<0.01 and p<0.0001, respectively), and in mothers post-delivery (p<0.01) when compared to non-pregnant control subjects. Furthermore, there was no significant effect of gestational time on IL-10 concentration. Results from the current study suggest that elevated IL-10 is a physiological consequence of normal healthy pregnancy. These findings help clarify previous conflicting results and establish a range for plasma levels of IL-10 in normal healthy pregnancy.
Publication Types:
Research Support, Non-U.S. Gov't (javascript:AL_get(this, 'ptyp', 'Research Support, Non-U.S. Gov't ');)
MeSH Terms:
Adjuvants, Immunologic/blood (javascript:AL_get(this, 'mesh', 'Adjuvants, Immunologic/blood');)
Adolescent (javascript:AL_get(this, 'mesh', 'Adolescent');)
Adult (javascript:AL_get(this, 'mesh', 'Adult');)
Female (javascript:AL_get(this, 'mesh', 'Female');)
Humans (javascript:AL_get(this, 'mesh', 'Humans');)
Interleukin-10/blood* (javascript:AL_get(this, 'mesh', 'Interleukin-10/blood*');)
Longitudinal Studies (javascript:AL_get(this, 'mesh', 'Longitudinal Studies');)
Postpartum Period (javascript:AL_get(this, 'mesh', 'Postpartum Period');)
Pregnancy/blood (javascript:AL_get(this, 'mesh', 'Pregnancy/blood');)
Pregnancy/immunology* (javascript:AL_get(this, 'mesh', 'Pregnancy/immunology*');)
Reference Values (javascript:AL_get(this, 'mesh', 'Reference Values');)
Substances:
Adjuvants, Immunologic (javascript:AL_get(this, 'subs', 'Adjuvants, Immunologic');)
 What kind of aggressive tropical freshwater fish go together? I want a ghost fish, African cichlids etc?
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